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Titel:

Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study.

Dokumenttyp:
journal article
Autor(en):
Köhler, Meike; Beyerlein, Andreas; Vehik, Kendra; Greven, Sonja; Umlauf, Nikolaus; Lernmark, Åke; Hagopian, William A; Rewers, Marian; She, Jin-Xiong; Toppari, Jorma; Akolkar, Beena; Krischer, Jeffrey P; Bonifacio, Ezio; Ziegler, Anette-G; TEDDY study group; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Bedoy, Ruth; Felipe-Morales, Daniel; Driscoll, Kimberly; Frohnert, Brigitte I; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Liu, Edwin; Norris, Jill; Samper-Imaz, Adela; Steck, An...     »
Abstract:
The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical models.We investigated data of 613 children from the prospective TEDDY study who were persistent positive fo...     »
Zeitschriftentitel:
Acta Diabetol
Jahr:
2017
Band / Volume:
54
Heft / Issue:
11
Seitenangaben Beitrag:
1009-1017
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00592-017-1033-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28856522
Print-ISSN:
0940-5429
TUM Einrichtung:
Klinik und Poliklinik für Kinder- und Jugendmedizin
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