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Titel:

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

Dokumenttyp:
Journal Article
Autor(en):
Zhu, Kaichuan; Xiang, Xianyuan; Filser, Severin; Marinkovi?, Petar; Dorostkar, Mario M; Crux, Sophie; Neumann, Ulf; Shimshek, Derya R; Rammes, Gerhard; Haass, Christian; Lichtenthaler, Stefan F; Gunnersen, Jenny M; Herms, Jochen
Abstract:
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheimer's disease. Prolonged BACE1 inhibition interferes with structural and functional synaptic plasticity in mice, most likely by altering the metabolism of BACE1 substrates. Seizure protein 6 (SEZ6) is predominantly cleaved by BACE1, and Sez6 knockout mice share some phenotypes with BACE1 inhibitor-treated mice. We investigated whether SEZ6 is involved in BACE1 inhibition-induced st...     »
Zeitschriftentitel:
Biol Psychiatry
Jahr:
2018
Band / Volume:
83
Heft / Issue:
5
Seitenangaben Beitrag:
428-437
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.biopsych.2016.12.023
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28129943
Print-ISSN:
0006-3223
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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