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Document type:
Journal Article 
Author(s):
Chung, Liam; Thiele Orberg, Erik; Geis, Abby L; Chan, June L; Fu, Kai; DeStefano Shields, Christina E; Dejea, Christine M; Fathi, Payam; Chen, Jie; Finard, Benjamin B; Tam, Ada J; McAllister, Florencia; Fan, Hongni; Wu, Xinqun; Ganguly, Sudipto; Lebid, Andriana; Metz, Paul; Van Meerbeke, Sara W; Huso, David L; Wick, Elizabeth C; Pardoll, Drew M; Wan, Fengyi; Wu, Shaoguang; Sears, Cynthia L; Housseau, Franck 
Title:
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. 
Abstract:
Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using ApcMin mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis (ETBF) as a model of microbe-induced colon tumorigenesis, we show that the Bacteroides fragilis toxin (BFT) triggers a pro-carcinogenic, multi-step inflammatory cascade requiring IL-17R, NF-κB, and Stat3 signaling in colonic epithelial cells (CECs). Although...    »
 
Journal title abbreviation:
Cell Host Microbe 
Year:
2018 
Journal volume:
23 
Journal issue:
Pages contribution:
203-214.e5 
Print-ISSN:
1931-3128 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)