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- Title:
The IPSS-R has prognostic impact in untreated patients with MDS del(5q).
- Document type:
- Journal Article
- Author(s):
- Kaivers, J; Lauseker, M; Hildebrandt, B; Fenaux, P; Pfeilstöcker, M; Valent, P; Platzbecker, U; Latagliata, R; Oliva, E N; Xicoy, B; Götze, K; Ganster, C; Haase, D; Bug, G; Kündgen, A; Gattermann, N; Haas, R; Germing, U
- Abstract:
- The IPSS-R proved to be a powerful tool for the assessment of prognosis in MDS patients. We aimed at a validation of the IPSS-R for patients with MDS harboring deletion (5q) isolated or accompanied by additional aberrations. The study was based on 444 MDS patients from MDS centers in Europe. 67% of the patients were female, median age was 69 years. 43.5% had MDS del(5q), 5.9% were diagnosed with RCUD, 2.0% RARS, 18.4% RCMD, 14.6% RAEB-I and 15.5% RAEB-II. According to the IPSS-R, there were 9.9% very low, 39.6% low, 16.6% intermediate, 12.8% high, 20.9% very high risk patients. For very low risk patients survival was 7.5 years, low 9.0 years, intermediate 6.5 years, high 1.5 years and very high 0.7 years (p < 0.001). For low and intermediate risk, the probability of AML evolution was significantly different (p = 0.03) as well as for high versus very high risk groups (p = 0.002). The IPSS-R proved to be an appropriate prognostic tool for MDS with del(5q).
- Journal title abbreviation:
- Leuk Res
- Year:
- 2018
- Journal volume:
- 72
- Pages contribution:
- 27-33
- Fulltext / DOI:
- doi:10.1016/j.leukres.2018.07.019
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30075323
- Print-ISSN:
- 0145-2126
- TUM Institution:
- III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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