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Title:

High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment.

Document type:
Journal Article; Journal Article
Author(s):
Müller, Jennifer-Christin; Lichtmannegger, Josef; Zischka, Hans; Sperling, Michael; Karst, Uwe
Abstract:
Wilson disease (WD) is a rare genetic disorder of the copper metabolism leading to systemic copper accumulation, predominantly in the liver. The therapeutic approach in WD patients is the generation of a negative copper balance and the maintenance of copper homeostasis, currently by the use of copper chelators such as D-penicillamine (D-PA). However, in circumstances of delayed diagnosis, poor treatment compliance, or treatment failure, mortality is almost certain without hepatic transplantation...     »
Journal title abbreviation:
J Trace Elem Med Biol
Year:
2018
Journal volume:
49
Pages contribution:
119-127
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jtemb.2018.05.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29895360
Print-ISSN:
0946-672X
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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