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Titel:

High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment.

Dokumenttyp:
Journal Article
Autor(en):
Muller, Jennifer-C; Lichtmannegger, Josef; Zischka, Hans; Sperling, Michael; Karst, Uwe
Abstract:
Wilson disease (WD) is a rare genetic disorder of the copper metabolism leading to systemic copper accumulation, predominantly in the liver. The therapeutic approach in WD patients is the generation of a negative copper balance and the maintenance of copper homeostasis, currently by the use of copper chelators such as D-penicillamine (D-PA). However, in circumstances of delayed diagnosis, poor treatment compliance, or treatment failure, mortality is almost certain without hepatic transplantation...     »
Zeitschriftentitel:
J Trace Elem Med Biol
Jahr:
2018
Band / Volume:
49
Seitenangaben Beitrag:
119-127
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jtemb.2018.05.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29895360
Print-ISSN:
0946-672X
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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