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Title:

Mitochondrial copper homeostasis and its derailment in Wilson disease.

Document type:
Journal Article
Author(s):
Zischka, Hans; Einer, Claudia
Abstract:
In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent on adequate copper supply for proper respiratory function, and the molecular mechanisms for metalation of the cytochrome c oxidase have been largely characterized. On the other hand, copper overload impairs mitochondria and uncertainties exist co...     »
Journal title abbreviation:
Int J Biochem Cell Biol
Year:
2018
Journal volume:
102
Pages contribution:
71-75
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biocel.2018.07.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29997057
Print-ISSN:
1357-2725
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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