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Titel:

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

Dokumenttyp:
Journal Article
Autor(en):
Ingold, Irina; Berndt, Carsten; Schmitt, Sabine; Doll, Sebastian; Poschmann, Gereon; Buday, Katalin; Roveri, Antonella; Peng, Xiaoxiao; Porto Freitas, Florencio; Seibt, Tobias; Mehr, Lisa; Aichler, Michaela; Walch, Axel; Lamp, Daniel; Jastroch, Martin; Miyamoto, Sayuri; Wurst, Wolfgang; Ursini, Fulvio; Arnér, Elias S J; Fradejas-Villar, Noelia; Schweizer, Ulrich; Zischka, Hans; Friedmann Angeli, José Pedro; Conrad, Marcus
Abstract:
Selenoproteins are rare proteins among all kingdoms of life containing the 21 amino acid, selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of selenium for sulfur. Yet the actual advantage of selenolate- versus thiolate-based catalysis has remained enigmatic, as most of the known selenoproteins also exist as cysteine-containing homologs. Here, we demonstrate that selenolate-based catalysis of the essential mammalian selenoprotein GPX4 is unexpectedly dispensab...     »
Zeitschriftentitel:
Cell
Jahr:
2018
Band / Volume:
172
Heft / Issue:
3
Seitenangaben Beitrag:
409-422.e21
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cell.2017.11.048
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29290465
Print-ISSN:
0092-8674
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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