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Titel:

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kaisar, Maria M M; Ritter, Manuel; del Fresno, Carlos; Jónasdóttir, Hulda S; van der Ham, Alwin J; Pelgrom, Leonard R; Schramm, Gabriele; Layland, Laura E; Sancho, David; Prazeres da Costa, Clarissa; Giera, Martin; Yazdanbakhsh, Maria; Everts, Bart
Abstract:
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive potent Th2 responses, triggers DCs to produce prostaglandin E2 (PGE2), which subsequently-in an autocrine manner-induces OX40 ligand (OX40L) expression to license these DCs to drive Th2 responses. Mechanistically, SEA was...     »
Zeitschriftentitel:
PLoS Biol
Jahr:
2018
Band / Volume:
16
Heft / Issue:
4
Volltext / DOI:
doi:10.1371/journal.pbio.2005504
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29668708
Print-ISSN:
1544-9173
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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