Many capillary electrophoretic methods cannot be hyphenated to mass spectrometry because of additives in the background electrolyte which interfere in the detection. In order to enable mass spectrometric detection in such approaches, an innovative two-dimensional capillary electrophoresis system was developed. Here, analytes were cut by a mechanical valve from a first, mass spectrometry incompatible, dimension. Subsequently, the analytes were separated from the interfering additives in a second dimension previous to the successful mass spectrometric detection.
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Many capillary electrophoretic methods cannot be hyphenated to mass spectrometry because of additives in the background electrolyte which interfere in the detection. In order to enable mass spectrometric detection in such approaches, an innovative two-dimensional capillary electrophoresis system was developed. Here, analytes were cut by a mechanical valve from a first, mass spectrometry incompatible, dimension. Subsequently, the analytes were separated from the interfering additives in a second...
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