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Titel:

SK2 channels regulate mitochondrial respiration and mitochondrial Ca uptake.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Honrath, Birgit; Matschke, Lina; Meyer, Tammo; Magerhans, Lena; Perocchi, Fabiana; Ganjam, Goutham K; Zischka, Hans; Krasel, Cornelius; Gerding, Albert; Bakker, Barbara M; Bünemann, Moritz; Strack, Stefan; Decher, Niels; Culmsee, Carsten; Dolga, Amalia M
Abstract:
Mitochondrial calcium ([Ca]) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death. Recently, SK channels were identified at the inner mitochondrial membrane, however, their particular role in the observed neuroprotection remains unclear. Here, we show a potential neuroprotective mechanism that involves attenuation of [Ca] uptake upon SK chann...     »
Zeitschriftentitel:
Cell Death Differ
Jahr:
2017
Band / Volume:
24
Heft / Issue:
5
Seitenangaben Beitrag:
761-773
Sprache:
eng
Volltext / DOI:
doi:10.1038/cdd.2017.2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28282037
Print-ISSN:
1350-9047
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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