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Document type:
Journal Article 
Author(s):
Badieyan, Zohreh Sadat; Pasewald, Tamara; Mykhaylyk, Olga; Rudolph, Carsten; Plank, Christian 
Title:
Efficient ex vivo delivery of chemically modified messenger RNA using lipofection and magnetofection. 
Abstract:
Recently, chemically modified mRNA (cmRNA) therapeutics have been the subject of extensive application-oriented research in both academia and industry as a safer alternative for gene and recombinant protein therapies. However, the lack of an efficient delivery system hinders widespread application. Here we used ~100-nm lipoplexes and magnetic lipoplexes that can protect cmRNA from RNases and efficiently deliver it into muscle and fat tissues as well as to the endothelium of the carotid artery. E...    »
 
Journal title abbreviation:
Biochem Biophys Res Commun 
Year:
2017 
Journal volume:
482 
Journal issue:
Pages contribution:
796-801 
Language:
eng 
Print-ISSN:
0006-291X 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung