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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Utzinger, Maximilian; Jarzebinska, Anita; Haag, Nicolas; Schweizer, Martin; Winter, Gerhard; Dohmen, Christian; Rudolph, Carsten; Plank, Christian 
Title:
cmRNA/lipoplex encapsulation in PLGA microspheres enables transfection via calcium phosphate cement (CPC)/PLGA composites. 
Abstract:
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by va...    »
 
Journal title abbreviation:
J Control Release 
Year:
2017 
Journal volume:
249 
Pages contribution:
143-149 
Language:
eng 
Print-ISSN:
0168-3659 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung