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Document type:
Journal Article 
Author(s):
Geyer, Antonia; Taschauer, Alexander; Alioglu, Fatih; Anton, Martina; Maier, Julia; Drothler, Elisabeth; Simlinger, Manuela; Yavuz, Sümeyye; Sami, Haider; Ogris, Manfred 
Title:
Multimodal Fluorescence and Bioluminescence Imaging Reveals Transfection Potential of Intratracheally Administered Polyplexes for Breast Cancer Lung Metastases. 
Abstract:
Local delivery of anticancer agents or gene therapeutics to lung tumors can circumvent side effects or accumulation in non-target organs, but accessibility via the alveolar side of the blood-air barrier remains challenging. Polyplexes based on plasmid and linear polyethylenimine (LPEI) transfect healthy lung tissue when applied intravenously (i.v.) in the mouse, but direct delivery into the lungs results in low transfection of lung tissue. Nevertheless, LPEI could offer the potential to transfec...    »
 
Journal title abbreviation:
Hum Gene Ther 
Year:
2017 
Journal volume:
28 
Journal issue:
12 
Pages contribution:
1202-1213 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1043-0342 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung