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Titel:

Non-invasive imaging of engineered human tumors in the living chicken embryo.

Dokumenttyp:
Journal Article; Article
Autor(en):
Jefferies, Benedict; Lenze, Florian; Sathe, Anuja; Truong, Nguyen; Anton, Martina; von Eisenhart-Rothe, Rüdiger; Nawroth, Roman; Mayer-Kuckuk, Philipp
Abstract:
The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate cancer (PC-3) and two osteosarcoma (MG63 and HOS) cell lines were modified with luciferase reporter genes. To create engineered tumors, these cell lines were seeded either onto basement...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2017
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
4991
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-017-04572-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28694510
Print-ISSN:
2045-2322
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Orthopädie und Sportorthopädie; Urologische Klinik und Poliklinik
 BibTeX