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Titel:

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

Dokumenttyp:
Journal Article
Autor(en):
Michler, Thomas; Große, Stefanie; Mockenhaupt, Stefan; Röder, Natalie; Stückler, Ferdinand; Knapp, Bettina; Ko, Chunkyu; Heikenwälder, Mathias; Protzer, Ulrike; Grimm, Dirk
Abstract:
Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end, we systematically compared different strategies to express anti-HBV short hairpin RNA (shRNA) in a pre-clinical immunocompetent hepatitis B mouse model. Using recombinant Adeno-associated virus (AAV) 8 vecto...     »
Zeitschriftentitel:
EMBO Mol Med
Jahr:
2016
Band / Volume:
8
Heft / Issue:
9
Seitenangaben Beitrag:
1082-98
Sprache:
eng
Volltext / DOI:
doi:10.15252/emmm.201506172
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27473329
Print-ISSN:
1757-4676
TUM Einrichtung:
Institut für Virologie
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