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Titel:

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

Dokumenttyp:
Article
Autor(en):
Lehmann, J; Vomacka, J; Esser, K; Nodwell, M; Kolbe, K; Ramer, P; Protzer, U; Reiling, N; Sieber, SA
Abstract:
Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.
Zeitschriftentitel:
MedChemComm
Jahr:
2016
Band / Volume:
7
Heft / Issue:
9
Seitenangaben Beitrag:
1797-1801
Sprache:
eng
Print-ISSN:
2040-2503
TUM Einrichtung:
Institut für Virologie
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