Benutzer: Gast  Login
Titel:

Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein.

Dokumenttyp:
Journal Article; Article
Autor(en):
Sautto, Giuseppe A; Wisskirchen, Karin; Clementi, Nicola; Castelli, Matteo; Diotti, Roberta A; Graf, Julia; Clementi, Massimo; Burioni, Roberto; Protzer, Ulrike; Mancini, Nicasio
Abstract:
The recent availability of novel antiviral drugs has raised new hope for a more effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in the case of non-responding or relapsing patients, alternative strategies are needed. To this end we have used chimeric antigen receptors (CARs), a very promising approach recently used in several clinical trials to redirect primary human T cells against different tumours. In particular, we designed the first CARs against HCV...     »
Zeitschriftentitel:
Gut
Jahr:
2016
Band / Volume:
65
Heft / Issue:
3
Seitenangaben Beitrag:
512-23
Sprache:
eng
Volltext / DOI:
doi:10.1136/gutjnl-2014-308316
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25661083
Print-ISSN:
0017-5749
TUM Einrichtung:
Institut für Virologie
 BibTeX