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Titel:

Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line.

Dokumenttyp:
Journal Article
Autor(en):
Broecker, Felix; Hardt, Christopher; Herwig, Ralf; Timmermann, Bernd; Kerick, Martin; Wunderlich, Andrea; Schweiger, Michal R; Borsig, Lubor; Heikenwälder, Mathias; Lehrach, Hans; Moelling, Karin
Abstract:
Deletions at the C-terminus of the proto-oncogene protein c-Src kinase are found in the viral oncogene protein v-Src as well as in some advanced human colon cancers. They are associated with increased kinase activity and cellular invasiveness. Here, we analyzed the mRNA expression signature of a constitutively active C-terminal mutant of c-Src, c-Src(mt), in comparison with its wild-type protein, c-Src(wt), in the human non-transformed breast epithelial cell line MCF-10A. We demonstrated previou...     »
Zeitschriftentitel:
FEBS J
Jahr:
2016
Band / Volume:
283
Heft / Issue:
9
Seitenangaben Beitrag:
1669-88
Sprache:
eng
Volltext / DOI:
doi:10.1111/febs.13694
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26919036
Print-ISSN:
1742-464X
TUM Einrichtung:
Institut für Virologie
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