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- Titel:
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
- Dokumenttyp:
- Article
- Autor(en):
- Lehmann, J; Vomacka, J; Esser, K; Nodwell, M; Kolbe, K; Ramer, P; Protzer, U; Reiling, N; Sieber, SA
- Abstract:
- Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.
- Zeitschriftentitel:
- MedChemComm
- Jahr:
- 2016
- Band / Volume:
- 7
- Heft / Issue:
- 9
- Seitenangaben Beitrag:
- 1797-1801
- Sprache:
- eng
- Print-ISSN:
- 2040-2503
- TUM Einrichtung:
- Institut für Virologie
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