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Title:

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.

Document type:
Journal Article; Article
Author(s):
Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela; Malo, Antje; Valls, Roser Marin; Wang, Fan; Reinert, Line S; Dagnaes-Hansen, Frederik; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm; Protzer, Ulrike; Paludan, Søren R
Abstract:
Hepatitis B virus (HBV) is a major human pathogen, and about one third of the global population will be exposed to the virus in their lifetime. HBV infects hepatocytes, where it replicates its DNA and infection can lead to acute and chronic hepatitis with a high risk of liver cirrhosis and hepatocellular carcinoma. Despite this, there is limited understanding of how HBV establishes chronic infections. In recent years it has emerged that foreign DNA potently stimulates the innate immune response,...     »
Journal title abbreviation:
Hepatology
Year:
2016
Journal volume:
64
Journal issue:
3
Pages contribution:
746-59
Language:
eng
Fulltext / DOI:
doi:10.1002/hep.28685
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27312012
Print-ISSN:
0270-9139
TUM Institution:
Institut für Virologie
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