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Titel:

Transcript-activated collagen matrix as sustained mRNA delivery system for bone regeneration.

Dokumenttyp:
Journal Article
Autor(en):
Badieyan, Zohreh Sadat; Berezhanskyy, Taras; Utzinger, Maximilian; Aneja, Manish Kumar; Emrich, Daniela; Erben, Reinhold; Schüler, Christiane; Altpeter, Philipp; Ferizi, Mehrije; Hasenpusch, Günther; Rudolph, Carsten; Plank, Christian
Abstract:
Transcript therapies using chemically modified messenger RNAs (cmRNAs) are emerging as safe and promising alternatives for gene and recombinant protein therapies. However, their applications have been limited due to transient translation and relatively low stability of cmRNAs compared to DNA. Here we show that vacuum-dried cmRNA-loaded collagen sponges, termed transcript activated matrices (TAMs), can serve as depots for sustained delivery of cmRNA. TAMs provide steady state protein production f...     »
Zeitschriftentitel:
J Control Release
Jahr:
2016
Band / Volume:
239
Seitenangaben Beitrag:
137-48
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jconrel.2016.08.037
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27586186
Print-ISSN:
0168-3659
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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