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Titel:

Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ferizi, Mehrije; Aneja, Manish K; Balmayor, Elizabeth R; Badieyan, Zohreh Sadat; Mykhaylyk, Olga; Rudolph, Carsten; Plank, Christian
Abstract:
Modified nucleotide chemistries that increase the half-life (T1/2) of transfected recombinant mRNA and the use of non-native 5'- and 3'-untranslated region (UTR) sequences that enhance protein translation are advancing the prospects of transcript therapy. To this end, a set of UTR sequences that are present in mRNAs with long cellular T1/2 were synthesized and cloned as five different recombinant sequence set combinations as upstream 5'-UTR and/or downstream 3'-UTR regions flanking a reporter ge...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2016
Band / Volume:
6
Seitenangaben Beitrag:
39149
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep39149
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27974853
Print-ISSN:
2045-2322
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Unfallchirurgie
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