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Title:

A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery.

Document type:
Journal Article
Author(s):
Jarz?bi?ska, Anita; Pasewald, Tamara; Lambrecht, Jana; Mykhaylyk, Olga; Kümmerling, Linda; Beck, Philipp; Hasenpusch, Günther; Rudolph, Carsten; Plank, Christian; Dohmen, Christian
Abstract:
The development of chemically modified mRNA holds great promise as a new class of biologic therapeutics. However, the intracellular delivery and endosomal escape of mRNA encapsulated in nanoparticles has not been systematically investigated. Here, we synthesized a diverse set of cationic polymers and lipids from a series of oligoalkylamines and subsequently characterized their mRNA delivery capability. Notably, a structure with an alternating alkyl chain length between amines showed the highest...     »
Journal title abbreviation:
Angew Chem Int Ed Engl
Year:
2016
Journal volume:
55
Journal issue:
33
Pages contribution:
9591-5
Language:
eng
Fulltext / DOI:
doi:10.1002/anie.201603648
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27376704
Print-ISSN:
1433-7851
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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