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Titel:

Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats.

Dokumenttyp:
Journal Article; Article
Autor(en):
Balmayor, Elizabeth R; Geiger, Johannes P; Aneja, Manish K; Berezhanskyy, Taras; Utzinger, Maximilian; Mykhaylyk, Olga; Rudolph, Carsten; Plank, Christian
Abstract:
Limitations associated to the use of growth factors represent a major hurdle to musculoskeletal regeneration. On the one hand, they are needed to induce neo-tissue formation for the substitution of a necrotic or missing tissue. On the other hand, these factors are used in supraphysiological concentrations, are short lived and expensive and result in many side effects. Here we develop a gene transfer strategy based on the use of chemically modified mRNA (cmRNA) coding for human bone morphogenetic...     »
Zeitschriftentitel:
Biomaterials
Jahr:
2016
Band / Volume:
87
Seitenangaben Beitrag:
131-46
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.biomaterials.2016.02.018
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26923361
Print-ISSN:
0142-9612
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Unfallchirurgie
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