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- Original title:
- Structural biology in peroxisome biogenesis
- Translated title:
- Strukturbiologie der Peroxisomenbiogenese
- Author:
- Emmanouilidis, Leonidas
- Year:
- 2016
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Sattler, Michael (Prof. Dr.)
- Referee:
- Sattler, Michael (Prof. Dr.); Buchner, Johannes (Prof. Dr.); Hell, Kai (Priv.-Doz. Dr.)
- Language:
- en
- Subject group:
- BIO Biowissenschaften; CHE Chemie
- TUM classification:
- CHE 808d; CHE 244d
- Abstract:
- Peroxisomes are organelles present in all eukaryotic cells, facilitating reactions that require oxidizing conditions. In this study biophysical methods and NMR-spectroscopy was used to study novel protein complexes involved in peroxisome biogenesis. Structure-based drug discovery was employed to develop antiparasitic drugs targeting a peroxisomal protein in trypansoma.
- Translated abstract:
- Peroxisomen sind Organellen die oxidative Reaktionen in eukaryontischen Zellen ermöglichen. In dieser Arbeit wurden mittels biophysikalischer Methoden und NMR-Spektroskopie neue Proteinkomplexe in der Peroxisomenbiogenese untersucht. Durch strukturbasierte Wirkstoffforschung wurden antiparasitische Inhibitoren eines peroxisomalen Proteins in Trypanosoma entwickelt.
- WWW:
- https://mediatum.ub.tum.de/?id=1316293
- Date of submission:
- 13.07.2016
- Oral examination:
- 12.09.2016
- File size:
- 39249696 bytes
- Pages:
- 140
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20160912-1316293-1-4
- Last change:
- 16.11.2016
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