Clinical Evaluation of Free-Breathing Contrast-Enhanced T1w MRI of the Liver using Pseudo Golden Angle Radial k-Space Sampling.

Hedderich, Dennis M; Weiss, Kilian; Spiro, Judith E; Giese, Daniel; Beck, Gabriele M; Maintz, David; Persigehl, Thorsten

doi:10.1055/s-0044-101263

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2018

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Title:: Clinical Evaluation of Free-Breathing Contrast-Enhanced T1w MRI of the Liver using Pseudo Golden Angle Radial k-Space Sampling.
Document type:: Journal Article; Randomized Controlled Trial
Author(s):: Hedderich, Dennis M; Weiss, Kilian; Spiro, Judith E; Giese, Daniel; Beck, Gabriele M; Maintz, David; Persigehl, Thorsten
Abstract:: PURPOSE: Contrast-enhanced T1-weighted MR imaging of the liver is typically acquired using breath-hold techniques to reduce motion artifacts and to allow for optimal diagnostic image quality. Insufficient breath-holds during MR data collection can cause severe reduction of image quality up to the point of being non-diagnostic. The aim of this study was to evaluate the subjective and objective clinical image quality of a novel free-breathing radial k-space sampling MR technique. MATERIALS AND METHODS: Consent for this study was given by the local IRB committee. 86 patients who underwent both breath-hold (BH) and free-breathing (FB) late-phase contrast T1w-FS-FFE liver MRI using conventional BH Cartesian (Cartesian-eTHRIVE) and FB "pseudo golden angle" radial k-space sampling (Radial-eTHRIVE) were included in this retrospective analysis. Subjective analysis comprised 5-point Likert scale ratings (1 = very good; 5 = non-diagnostic) for "artifact impact", "anatomic sharpness", "vessel sharpness", "contrast impression", and "overall diagnostic quality". Relative signal intensities in different ROIs were compared between Cartesian-eTHRIVE and Radial-eTHRIVE. For statistical differences paired Wilcoxon test and paired t-test have been performed (p < 0.05). RESULTS: The MR scan time was significantly longer for FB Radial-eTHRIVE (2 min, 54 s) compared to BH Cartesian-eTHRIVE (0 min 15 s). Cartesian-eTHRIVE demonstrated a superior subjective contrast impression and objective measurements revealed an increased lesion-to-liver-contrast for hypointense liver lesions (Hypo-LTLC: 0.33 ± 0.19 vs. 0.20 ± 0.11; p = 0.000), while no difference was observed for hyperintense liver lesions (Hyper-LTLC). Subjective evaluation showed superior anatomic sharpness ratings by both readers for Radial-eTHRIVE. Most importantly, in a subgroup analysis of patients who were unable to perform adequate breath-holds, free-breathing Radial-eTHRIVE still demonstrated good subjective image quality. CONCLUSION: Free-breathing, radial k-space sampling T1w MRI of the liver delivers high diagnostic image quality, especially in patients who are unable to adequately perform breath-hold maneuvers. Thus, Radial-eTHRIVE can be an important clinical alternative in patients with impaired respiration status. KEY POINTS: · Delayed-phase contrast-enhanced MRI of the liver can be robustly performed using a "pseudo golden angle" Radial-eTHRIVE sequence.. · Free-breathing Radial-eTHRIVE yields good diagnostic image quality in case of a high artifact burden in breath-hold Cartesian-eTHRIVE and thus could be used as a "back-up" for patients with impaired respiratory capacity.. · A lower lesion-to-liver-contrast ratio is observed for hypointense liver lesions in free-breathing Radial-eTHRIVE sequence.. CITATION FORMAT: · Hedderich DM, Weiss K, Spiro JE et al. Clinical Evaluation of Free-Breathing Contrast-Enhanced T1w MRI of the Liver using Pseudo Golden Angle Radial k-Space Sampling. Fortschr Röntgenstr 2018; 190: 601 - 609.
Journal title abbreviation:: Rofo
Year:: 2018
Journal volume:: 190
Journal issue:: 7
Pages contribution:: 601-609
Fulltext / DOI:: doi:10.1055/s-0044-101263
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/29534252
Print-ISSN:: 1438-9029
TUM Institution:: Fachgebiet Neuroradiologie (Prof. Zimmer)
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