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Titel:

Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.

Dokumenttyp:
Journal Article
Autor(en):
Kong, Bo; Bruns, Philipp; Behler, Nora A; Chang, Ligong; Schlitter, Anna Melissa; Cao, Jing; Gewies, Andreas; Ruland, Jürgen; Fritzsche, Sina; Valkovskaya, Nataliya; Jian, Ziying; Regel, Ivonne; Raulefs, Susanne; Irmler, Martin; Beckers, Johannes; Friess, Helmut; Erkan, Mert; Mueller, Nikola S; Roth, Susanne; Hackert, Thilo; Esposito, Irene; Theis, Fabian J; Kleeff, Jörg; Michalski, Christoph W
Abstract:
The initial steps of pancreatic regeneration versus carcinogenesis are insufficiently understood. Although a combination of oncogenic Kras and inflammation has been shown to induce malignancy, molecular networks of early carcinogenesis remain poorly defined.We compared early events during inflammation, regeneration and carcinogenesis on histological and transcriptional levels with a high temporal resolution using a well-established mouse model of pancreatitis and of inflammation-accelerated Kras...     »
Zeitschriftentitel:
Gut
Jahr:
2018
Band / Volume:
67
Heft / Issue:
1
Seitenangaben Beitrag:
146-156
Sprache:
eng
Volltext / DOI:
doi:10.1136/gutjnl-2015-310913
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27646934
Print-ISSN:
0017-5749
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie
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