Benutzer: Gast  Login
Titel:

Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy.

Dokumenttyp:
Journal Article
Autor(en):
Schulze, Sarah; Stöß, Christian; Lu, Miao; Wang, Baocai; Laschinger, Melanie; Steiger, Katja; Altmayr, Felicitas; Friess, Helmut; Hartmann, Daniel; Holzmann, Bernhard; Hüser, Norbert
Abstract:
Stimulation of cytosolic nucleic acid sensors of innate immunity by pathogen-derived nucleic acids is important for antimicrobial defence, but stimulation through self-derived nucleic acids may contribute to autoinflammation and cancer. DNA sensing in the cytosol requires the stimulator of interferon genes (STING), while cytosolic RNA sensors use mitochondrial antiviral-signalling protein (MAVS). In a murine model of two-thirds hepatectomy, combined deficiency of MAVS and STING resulted in stron...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2018
Band / Volume:
8
Heft / Issue:
1
Seitenangaben Beitrag:
12271
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-018-29924-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30115978
Print-ISSN:
2045-2322
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX