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Title:

Pharmacoproteomic characterisation of human colon and rectal cancer

Document type:
Zeitschriftenaufsatz
Author(s):
Frejno, Martin; Zenezini Chiozzi, Riccardo; Wilhelm, Mathias; Koch, Heiner; Zheng, Runsheng; Klaeger, Susan; Ruprecht, Benjamin; Meng, Chen; Kramer, Karl; Jarzab, Anna; Heinzlmeir, Stephanie; Johnstone, Elaine; Domingo, Enric; Kerr, David; Jesinghaus, Moritz; Slotta‐Huspenina, Julia; Weichert, Wilko; Knapp, Stefan; Feller, Stephan M; Kuster, Bernhard
Abstract:
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome‐guided pre‐clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of each tumo...     »
Journal title:
Molecular Systems Biology
Year:
2017
Journal volume:
13
Journal issue:
11
Pages contribution:
951
Fulltext / DOI:
doi:10.15252/msb.20177701
Publisher:
EMBO
E-ISSN:
1744-42921744-42921744-4292
Date of publication:
01.11.2017
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