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Titel:

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.

Dokumenttyp:
Journal Article; 13
Autor(en):
Stojanovic, N; Hassan, Z; Wirth, M; Wenzel, P; Beyer, M; Schäfer, C; Brand, P; Kroemer, A; Stauber, R H; Schmid, R M; Arlt, A; Sellmer, A; Mahboobi, S; Rad, R; Reichert, M; Saur, D; Krämer, O H; Schneider, G
Abstract:
Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert tumour-promoting functions, qualifying them as important therapeutic targets. Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the expression of p53 mutants in human and genetically defined murine pancreatic cancer cells. Our data reveal that the inh...     »
Zeitschriftentitel:
Oncogene
Jahr:
2017
Band / Volume:
36
Heft / Issue:
13
Seitenangaben Beitrag:
1804-1815
Sprache:
eng
Volltext / DOI:
doi:10.1038/onc.2016.344
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27721407
Print-ISSN:
0950-9232
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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