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Titel:

Methanobactin reverses acute liver failure in a rat model of Wilson disease.

Dokumenttyp:
Journal Article
Autor(en):
Lichtmannegger, Josef; Leitzinger, Christin; Wimmer, Ralf; Schmitt, Sabine; Schulz, Sabine; Kabiri, Yaschar; Eberhagen, Carola; Rieder, Tamara; Janik, Dirk; Neff, Frauke; Straub, Beate K; Schirmacher, Peter; DiSpirito, Alan A; Bandow, Nathan; Baral, Bipin S; Flatley, Andrew; Kremmer, Elisabeth; Denk, Gerald; Reiter, Florian P; Hohenester, Simon; Eckardt-Schupp, Friedericke; Dencher, Norbert A; Adamski, Jerzy; Sauer, Vanessa; Niemietz, Christoph; Schmidt, Hartmut H J; Merle, Uta; Gotthardt, Danie...     »
Abstract:
In Wilson disease (WD), functional loss of ATPase copper-transporting ? (ATP7B) impairs biliary copper excretion, leading to excessive copper accumulation in the liver and fulminant hepatitis. Current US Food and Drug Administration- and European Medicines Agency-approved pharmacological treatments usually fail to restore copper homeostasis in patients with WD who have progressed to acute liver failure, leaving liver transplantation as the only viable treatment option. Here, we investigated the...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2016
Band / Volume:
126
Heft / Issue:
7
Seitenangaben Beitrag:
2721-35
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI85226
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27322060
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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