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Title:

Probing Blood Plasma Protein Glycosylation with Infrared Spectroscopy

Document type:
Zeitschriftenaufsatz
Author(s):
Voronina, Liudmila; Fleischmann, Frank; Šimunović, Jelena; Ludwig, Christina; Novokmet, Mislav; Žigman, Mihaela
Abstract:
The health state of an individual is closely linked to the glycosylation patterns of his or her blood plasma proteins. However, obtaining this information requires cost- and time-efficient analytical methods. We put forward infrared spectroscopy, which allows label-free analysis of protein glycosylation but so far has only been applied to analysis of individual proteins. Although spectral information does not directly provide the molecular structure of the glycans, it is sensitive to changes the...     »
Keywords:
BayBioMS; Anatomy,Carbohydrates,Chemical biology,Peptides and proteins,Post-translational modification
Journal title:
Analytical Chemistry
Year:
2024
Fulltext / DOI:
doi:10.1021/acs.analchem.3c03589
Publisher:
American Chemical Society (ACS)
E-ISSN:
0003-27001520-6882
Date of publication:
07.02.2024
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