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Title:

Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS

Document type:
Zeitschriftenaufsatz
Author(s):
Rosenberger, George; Liu, Yansheng; Röst, Hannes L; Ludwig, Christina; Buil, Alfonso; Bensimon, Ariel; Soste, Martin; Spector, Tim D; Dermitzakis, Emmanouil T; Collins, Ben C; Malmström, Lars; Aebersold, Ruedi
Abstract:
Consistent detection and quantification of protein post-translational modifications (PTMs) across sample cohorts is a prerequisite for functional analysis of biological processes. Data-independent acquisition (DIA) is a bottom-up mass spectrometry approach that provides complete information on precursor and fragment ions. However, owing to the convoluted structure of DIA data sets, confident, systematic identification and quantification of peptidoforms has remained challenging. Here, we present...     »
Journal title:
Nature Biotechnology
Year:
2017
Fulltext / DOI:
doi:10.1038/nbt.3908
Publisher:
Springer Nature
E-ISSN:
1087-01561546-1696
Date of publication:
12.06.2017
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