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Title:

A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts

Document type:
Zeitschriftenaufsatz
Author(s):
Hoermann, Bernhard; Dürr, Eva-Maria; Ludwig, Christina; Ercan, Melda; Köhn, Maja
Abstract:
Chemical activators and inhibitors are useful probes to identify substrates and downstream effects of enzymes; however, due to the complex signaling environment within cells, it is challenging to distinguish between direct and indirect effects. This is particularly the case for phosphorylation, where a single (de)phosphorylation event can trigger rapid changes in many other phosphorylation sites. An additional complication arises when a single catalytic entity, which acts in the form of many di...     »
Keywords:
BayBioMS;
Journal title:
Chemical Science
Year:
2024
Journal volume:
15
Journal issue:
8
Pages contribution:
2792-2804
Fulltext / DOI:
doi:10.1039/d3sc04746f
Publisher:
Royal Society of Chemistry (RSC)
E-ISSN:
2041-65202041-6539
Date of publication:
01.01.2024
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