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Title:

Inactive Gingipains from Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Glowczyk, Izabela; Wong, Alicia; Potempa, Barbara; Babyak, Olena; Lech, Maciej; Lamont, Richard J; Potempa, Jan; Koziel, Joanna
Abstract:
Gingipain cysteine proteases are considered key virulence factors of . They significantly influence antibacterial and homeostatic functions of macrophages, neutrophils, the complement system, and cytokine networks. Recent data indicate the role of in T cell differentiation; however, the involvement of gingipains in this process remains elusive. Therefore, the aim of this study was to investigate the contribution of danger signals triggered by the gingipains on the generation of Th17 cells, whi...     »
Journal title abbreviation:
Front Cell Infect Microbiol
Year:
2017
Journal volume:
7
Pages contribution:
140
Fulltext / DOI:
doi:10.3389/fcimb.2017.00140
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28497028
Print-ISSN:
2235-2988
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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