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Titel:

Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Meinhold, Marius; Verbrugge, Sander; Shi, Andi; Schönfelder, Martin; Becker, Lore; Jaspers, Richard T.; Zammit, Peter S.; Wackerhage, Henning
Abstract:
In skeletal muscle, the Hippo effector Yap promotes satellite cell, myoblast, and rhabdomyoblast proliferation but prevents myogenic differentiation into multinucleated muscle fibres. We previously noted that Yap drives expression of the first enzyme of the serine biosynthesis pathway, phosphoglycerate dehydrogenase (Phgdh). Here, we examined the regulation and function of Phgdh in satellite cells and myoblasts and found that Phgdh protein increased during satellite cell activation. Analysis of...     »
Dewey Dezimalklassifikation:
570 Biowissenschaften, Biologie
Zeitschriftentitel:
Cell and Tissue Research
Jahr:
2024
Jahr / Monat:
2024-01
Quartal:
1. Quartal
Monat:
Jan
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1007/s00441-023-03851-w
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38183459
WWW:
https://link.springer.com/article/10.1007/s00441-023-03851-w
Verlag / Institution:
Springer Science and Business Media LLC
E-ISSN:
0302-766X1432-0878
Impact Factor:
3,6
Scimago-Quartil:
Q1
Hinweise:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Publikationsdatum:
06.01.2024
Semester:
WS 23-24
TUM Einrichtung:
Sportbiologie
Format:
Bild/Text
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