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Titel:

Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Arbiser, Jack L; Nowak, Ron; Michaels, Kellie; Skabytska, Yuliya; Biedermann, Tilo; Lewis, Monica J; Bonner, Michael Y; Rao, Shikha; Gilbert, Linda C; Yusuf, Nabiha; Karlsson, Isabella; Fritz, Yi; Ward, Nicole L
Abstract:
Psoriasis is a chronic inflammatory skin disease affecting 2.5-6 million patients in the United States. The cause of psoriasis remains unknown. Previous human and animal studies suggest that patients with a susceptible genetic background and some stimulus, such as barrier disruption, leads to a coordinated signaling events involving cytokines between keratinocytes, endothelial cells, T cells, macrophages and dendritic cells. Ceramides are endogenous skin lipids essential for maintaining skin bar...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2017
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
11198
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-017-10580-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28894119
Print-ISSN:
2045-2322
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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