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Titel:

In Vivo Imaging Reveals Rapid Astrocyte Depletion and Axon Damage in a Model of Neuromyelitis Optica-Related Pathology

Dokumenttyp:
journal article
Autor(en):
Herwerth, M; Kalluri, SR; Srivastava, R; Kleele, T; Kenet, S; Illes, Z; Merkler, D; Bennett, JL; Misgeld, T; Hemmer, B
Abstract:
Objective: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry immunoglobulin G autoantibodies against aquaporin-4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes by complement, but NMO histopathology also show...     »
Zeitschriftentitel:
Ann Neurol
Jahr:
2016
Band / Volume:
79
Heft / Issue:
5
Seitenangaben Beitrag:
794-805
Sprache:
eng
Volltext / DOI:
doi:10.1002/ana.24630
Print-ISSN:
0364-5134
TUM Einrichtung:
Neurologische Klinik und Poliklinik; Institut für Zellbiologie des Nervensystems
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