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Titel:

Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone.

Dokumenttyp:
Journal Article; Article
Autor(en):
Bunk, Eva C; Ertaylan, Gökhan; Ortega, Felipe; Pavlou, Maria A; Gonzalez Cano, Laura; Stergiopoulos, Athanasios; Safaiyan, Shima; Völs, Sandra; van Cann, Marianne; Politis, Panagiotis K; Simons, Mikael; Berninger, Benedikt; Del Sol, Antonio; Schwamborn, Jens C
Abstract:
Adult neural stem cells with the ability to generate neurons and glia cells are active throughout life in both the dentate gyrus (DG) and the subventricular zone (SVZ). Differentiation of adult neural stem cells is induced by cell fate determinants like the transcription factor Prox1. Evidence has been provided for a function of Prox1 as an inducer of neuronal differentiation within the DG. We now show that within the SVZ Prox1 induces differentiation into oligodendrocytes. Moreover, we find tha...     »
Zeitschriftentitel:
Stem Cells
Jahr:
2016
Band / Volume:
34
Heft / Issue:
8
Seitenangaben Beitrag:
2115-29
Sprache:
eng
Volltext / DOI:
doi:10.1002/stem.2374
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27068685
Print-ISSN:
1066-5099
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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