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Titel:

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.

Dokumenttyp:
Journal Article
Autor(en):
Herwerth, Marina; Kalluri, Sudhakar Reddy; Srivastava, Rajneesh; Kleele, Tatjana; Kenet, Selin; Illes, Zsolt; Merkler, Doron; Bennett, Jeffrey L; Misgeld, Thomas; Hemmer, Bernhard
Abstract:
Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry immunoglobulin G autoantibodies against aquaporin-4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes by complement, but NMO histopathology also shows demyelina...     »
Zeitschriftentitel:
Ann Neurol
Jahr:
2016
Band / Volume:
79
Heft / Issue:
5
Seitenangaben Beitrag:
794-805
Sprache:
eng
Volltext / DOI:
doi:10.1002/ana.24630
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26946517
Print-ISSN:
0364-5134
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld); Neurologische Klinik und Poliklinik
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