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- Title:
Prediction of all-cause death using (11)C-hydroxyephedrine positron emission tomography in Japanese patients with left ventricular dysfunction.
- Document type:
- Journal Article
- Author(s):
- Fujita, Wataru; Matsunari, Ichiro; Aoki, Hirofumi; Nekolla, Stephan G; Kajinami, Kouji
- Abstract:
- The aim of this study was to determine whether (11)C-hydroxyephedrine ((11)C-HED) can predict adverse events including all-cause death in Japanese patients with left ventricular (LV) dysfunction.Although (11)C-HED PET has been used to assess cardiac sympathetic innervation in various disease conditions, data on their prognostic value are limited.Sixty patients (mean LVEF, 42 ± 14 %) with LV dysfunction (42 ischemic and 18 non-ischemic heart disease) underwent (11)C-HED PET. Myocardial retention was calculated for (11)C-HED PET as a measure of cardiac sympathetic neuronal integrity. Statistical analysis was performed using Cox proportional hazards regression and log-rank test.Thirteen deaths (7 cardiac and 6 non-cardiac deaths) occurred during a mean follow-up period of 33 ± 23 months. The patients with death were associated with significantly lower (11)C-HED retention (7.1 ± 2.1 vs 9.0 ± 2.4, p = 0.015) than those without death. The hazard ratio for global (11)C-HED retention per unit (/min) was 0.762 (p = 0.039), which remained significant in multivariate analysis. When the patients were divided into the high (>=8.5) and low (<8.5) (11)C-HED retention groups, the low (11)C-HED retention group was associated with significantly poorer survival than the high (11)C-HED retention group (p = 0.004).The low global (11)C-HED retention is a marker of poor overall survival in patients with LV dysfunction in this study.
- Journal title abbreviation:
- Ann Nucl Med
- Year:
- 2016
- Journal volume:
- 30
- Journal issue:
- 7
- Pages contribution:
- 461-7
- Language:
- eng
- Fulltext / DOI:
- doi:10.1007/s12149-016-1081-z
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/27194040
- Print-ISSN:
- 0914-7187
- TUM Institution:
- Klinik und Poliklinik für Nuklearmedizin
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