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Title:

Long noncoding RNA Chast promotes cardiac remodeling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Viereck, Janika; Kumarswamy, Regalla; Foinquinos, Ariana; Xiao, Ke; Avramopoulos, Petros; Kunz, Meik; Dittrich, Marcus; Maetzig, Tobias; Zimmer, Karina; Remke, Janet; Just, Annette; Fendrich, Jasmin; Scherf, Kristian; Bolesani, Emiliano; Schambach, Axel; Weidemann, Frank; Zweigerdt, Robert; de Windt, Leon J; Engelhardt, Stefan; Dandekar, Thomas; Batkai, Sandor; Thum, Thomas
Abstract:
Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in cardiac development. However, understanding of lncRNAs in cardiac diseases is still limited. Global lncRNA expression profiling indicated that several lncRNA transcripts are deregulated during pressure overload-induced cardiac hypertrophy in mice. Using stringent selection criteria, we identified Chast (cardiac hypertrophy-associated transcript) as a potential lncRNA candidate that influences cardiomyocyte hype...     »
Journal title abbreviation:
Sci Transl Med
Year:
2016
Journal volume:
8
Journal issue:
326
Pages contribution:
326ra22
Language:
eng
Fulltext / DOI:
doi:10.1126/scitranslmed.aaf1475
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26888430
Print-ISSN:
1946-6234
TUM Institution:
Institut für Pharmakologie und Toxikologie
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