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Title:

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.

Document type:
Journal Article; Article
Author(s):
Brill, Monika S; Kleele, Tatjana; Ruschkies, Laura; Wang, Mengzhe; Marahori, Natalia A; Reuter, Miriam S; Hausrat, Torben J; Weigand, Emily; Fisher, Matthew; Ahles, Andrea; Engelhardt, Stefan; Bishop, Derron L; Kneussel, Matthias; Misgeld, Thomas
Abstract:
Developmental axon remodeling is characterized by the selective removal of branches from axon arbors. The mechanisms that underlie such branch loss are largely unknown. Additionally, how neuronal resources are specifically assigned to the branches of remodeling arbors is not understood. Here we show that axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, which results in local disassembly of the microtubule cytoskeleton and loss o...     »
Journal title abbreviation:
Neuron
Year:
2016
Journal volume:
92
Journal issue:
4
Pages contribution:
845-856
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuron.2016.09.049
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27773584
Print-ISSN:
0896-6273
TUM Institution:
Institut für Pharmakologie und Toxikologie; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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