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Title:

Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin.

Document type:
Journal Article; Article
Author(s):
Wetzl, Veronika; Schinner, Elisabeth; Kees, Frieder; Hofmann, Franz; Faerber, Lothar; Schlossmann, Jens
Abstract:
Kidney fibrosis has shown to be ameliorated through the involvement of cyclic guanosine monophosphate (cGMP) and its dependent protein kinase I (cGKI). Serelaxin, the recombinant form of human relaxin-II, increases cGMP levels and has shown beneficial effects on kidney function in acute heart failure patients. Antifibrotic properties of serelaxin are supposed to be mediated via relaxin family peptide receptor 1 and subsequently enhanced nitric oxide/cGMP to inhibit transforming growth factor-? (...     »
Journal title abbreviation:
Front Pharmacol
Year:
2016
Journal volume:
7
Pages contribution:
195
Language:
eng
Fulltext / DOI:
doi:10.3389/fphar.2016.00195
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27462268
TUM Institution:
Institut für Pharmakologie und Toxikologie
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