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Titel:

Long noncoding RNA Chast promotes cardiac remodeling.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Viereck, Janika; Kumarswamy, Regalla; Foinquinos, Ariana; Xiao, Ke; Avramopoulos, Petros; Kunz, Meik; Dittrich, Marcus; Maetzig, Tobias; Zimmer, Karina; Remke, Janet; Just, Annette; Fendrich, Jasmin; Scherf, Kristian; Bolesani, Emiliano; Schambach, Axel; Weidemann, Frank; Zweigerdt, Robert; de Windt, Leon J; Engelhardt, Stefan; Dandekar, Thomas; Batkai, Sandor; Thum, Thomas
Abstract:
Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in cardiac development. However, understanding of lncRNAs in cardiac diseases is still limited. Global lncRNA expression profiling indicated that several lncRNA transcripts are deregulated during pressure overload-induced cardiac hypertrophy in mice. Using stringent selection criteria, we identified Chast (cardiac hypertrophy-associated transcript) as a potential lncRNA candidate that influences cardiomyocyte hype...     »
Zeitschriftentitel:
Sci Transl Med
Jahr:
2016
Band / Volume:
8
Heft / Issue:
326
Seitenangaben Beitrag:
326ra22
Sprache:
eng
Volltext / DOI:
doi:10.1126/scitranslmed.aaf1475
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26888430
Print-ISSN:
1946-6234
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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