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Titel:

miR-184 Regulates Pancreatic ?-Cell Function According to Glucose Metabolism.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Tattikota, Sudhir G; Rathjen, Thomas; Hausser, Jean; Khedkar, Aditya; Kabra, Uma D; Pandey, Varun; Sury, Matthias; Wessels, Hans-Hermann; Mollet, Inês G; Eliasson, Lena; Selbach, Matthias; Zinzen, Robert P; Zavolan, Mihaela; Kadener, Sebastian; Tschöp, Matthias H; Jastroch, Martin; Friedländer, Marc R; Poy, Matthew N
Abstract:
In response to fasting or hyperglycemia, the pancreatic ?-cell alters its output of secreted insulin; however, the pathways governing this adaptive response are not entirely established. Although the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the ?-cell, regulates compensatory proliferation and secretion during insulin resistance. Consistent with previous stud...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2015
Band / Volume:
290
Heft / Issue:
33
Seitenangaben Beitrag:
20284-94
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M115.658625
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26152724
Print-ISSN:
0021-9258
TUM Einrichtung:
Kliniken und Institute
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