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Titel:

Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.

Dokumenttyp:
Journal Article
Autor(en):
Zhang, Shu; Huang, Shuling; Deng, Chao; Cao, Yu; Yang, Jun; Chen, Guangxia; Zhang, Bin; Duan, Chaoqin; Shi, Jiong; Kong, Bo; Friess, Helmut; Zhao, Nanyi; Huang, Chen; Huang, Xiaoli; Wang, Lei; Zou, Xiaoping
Abstract:
In many gastric cancer patients, the disease is diagnosed in an advanced stage and therefore the mortality levels are high. Because there is a need to identify novel early diagnostic and prognostic biomarkers, we tested whether SIRT1 and STAT3 are good candidates. Towards this, we used patient tissues representing different stages of gastric cancer including gastric pre-cancerous lesions, early gastric cancer, and advanced gastric cancer, and probed SIRT1, STAT3 and phosphorylated STAT3 (pSTAT3)...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2017
Band / Volume:
8
Heft / Issue:
12
Seitenangaben Beitrag:
18848-18860
Sprache:
eng
Volltext / DOI:
doi:10.18632/oncotarget.14473
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28061480
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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