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Titel:

Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Neuhaus, Klaus; Landstorfer, Richard; Fellner, Lea; Simon, Svenja; Schafferhans, Andrea; Goldberg, Tatyana; Marx, Harald; Ozoline, Olga N.; Rost, Burkhard; Kuster, Bernhard; Keim, Daniel A.; Scherer, Siegfried
Abstract:
BACKGROUND: Genomes of E. coli, including that of the human pathogen Escherichia coli O157:H7 (EHEC) EDL933, still harbor undetected protein-coding genes which, apparently, have escaped annotation due to their small size and non-essential function. To find such genes, global gene expression of EHEC EDL933 was examined, using strand-specific RNAseq (transcriptome), ribosomal footprinting (translatome) and mass spectrometry (proteome). RESULTS: Using the above methods, 72 short, non-annotated prot...     »
Stichworte:
BayBioMS
Zeitschriftentitel:
BMC Genomics
Jahr:
2016
Band / Volume:
17
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s12864-016-2456-1
Verlag / Institution:
Springer Nature
E-ISSN:
1471-2164
Publikationsdatum:
24.02.2016
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