Benutzer: Gast  Login
Titel:

Ethylene glycol improves electrospray ionization efficiency in bottom-up proteomics

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Yu, Peng; Hahne, Hannes; Wilhelm, Mathias; Kuster, Bernhard
Abstract:
Liquid chromatography coupled online to nano-electrospray ionization (nESI) tandem mass spectrometry is the analytical workhorse in the field of proteome research. Dimethyl sulfoxide (DMSO) was recently shown to improve nESI efficiency by a factor of three to ten thus improving the sensitivity and coverage of proteomic experiments. However, relatively few investigations into which solvent additives promote nESI response have been performed at a proteomic scale. Here, we systematically evaluated...     »
Stichworte:
BayBioMS
Zeitschriftentitel:
Analytical and Bioanalytical Chemistry
Jahr:
2016
Band / Volume:
409
Heft / Issue:
4
Seitenangaben Beitrag:
1049-1057
Volltext / DOI:
doi:10.1007/s00216-016-0023-x
Verlag / Institution:
Springer Nature
E-ISSN:
1618-26421618-2650
Publikationsdatum:
20.10.2016
 BibTeX